Detalhe da pesquisa
1.
Targeted protein degradation: from mechanisms to clinic.
Nat Rev Mol Cell Biol
; 2024 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38684868
2.
Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2.
Cell
; 181(3): 702-715.e20, 2020 04 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32315619
3.
Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.
Cell
; 174(2): 300-311.e11, 2018 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30007416
4.
Retraction Notice to: Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2.
Cell
; 185(16): 3058, 2022 08 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35931023
5.
Structural basis of regulated m7G tRNA modification by METTL1-WDR4.
Nature
; 613(7943): 391-397, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36599985
6.
MEN1 mutations mediate clinical resistance to menin inhibition.
Nature
; 615(7954): 913-919, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36922589
7.
Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of KMT2A-r and NPM1c AML.
Blood
; 143(15): 1513-1527, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38096371
8.
Small-molecule-induced polymerization triggers degradation of BCL6.
Nature
; 588(7836): 164-168, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33208943
9.
Structural characterization of methylation-independent PP2A assembly guides alphafold2Multimer prediction of family-wide PP2A complexes.
J Biol Chem
; 300(5): 107268, 2024 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38582449
10.
Overcoming IMiD resistance in T-cell lymphomas through potent degradation of ZFP91 and IKZF1.
Blood
; 139(13): 2024-2037, 2022 03 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-34936696
11.
E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance.
J Am Chem Soc
; 145(2): 1176-1184, 2023 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36602777
12.
Anti-SARS-CoV-2 activity of targeted kinase inhibitors: Repurposing clinically available drugs for COVID-19 therapy.
J Med Virol
; 95(1): e28157, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36117402
13.
Acute pharmacological degradation of Helios destabilizes regulatory T cells.
Nat Chem Biol
; 17(6): 711-717, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34035522
14.
Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader.
Angew Chem Int Ed Engl
; 62(18): e202302364, 2023 04 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36898968
15.
Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15.
Nat Chem Biol
; 16(1): 7-14, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31686031
16.
Bruton tyrosine kinase degradation as a therapeutic strategy for cancer.
Blood
; 133(9): 952-961, 2019 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30545835
17.
Local Deuteration Enables NMR Observation of Methyl Groups in Proteins from Eukaryotic and Cell-Free Expression Systems.
Angew Chem Int Ed Engl
; 60(25): 13783-13787, 2021 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33768661
18.
Plasticity in binding confers selectivity in ligand-induced protein degradation.
Nat Chem Biol
; 14(7): 706-714, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29892083
19.
Mutant-Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug-Resistant Mutations.
Angew Chem Int Ed Engl
; 59(34): 14481-14489, 2020 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32510788
20.
Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding.
Chemistry
; 25(8): 2019-2024, 2019 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30427558